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Medical information Clinical review pending

Genetic Testing

IRF6 Gene Orofacial Cleft Type 6 Genetic Test

Genetic test to identify mutations in the IRF6 gene associated with orofacial clefts (cleft lip and/or palate). Helps understand genetic risks and inform family planning.

General information only: This page is not a diagnosis or personal medical advice. A qualified clinician should decide whether testing is appropriate and interpret results in context.

Review status: No completed medical review is recorded for this page.

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Counselor guidance included Confidential handling Kenya-wide coordination

At a glance

Plan your test

Sample
Blood sample (EDTA tube), extracted DNA, or one drop of blood on an FTA card.
Results
Approximately 3 to 4 weeks. Confirm with the laboratory before booking.
Preparation
No specific patient preparation is required. Please provide a detailed clinical history and family history prior to the test. A genetic counseling session is recommended before testing.
Test priceKSh 40,000

Payment: M-Pesa and card options can be confirmed during booking.

Insurance & government schemes

Is this test covered for you?

We help you verify whether the IRF6 Gene Orofacial Cleft Type 6 Genetic Test test can be claimed against your insurer, employer scheme or a Kenyan government health scheme — before you book. Coverage depends on your plan, clinical indication and your provider's rules; final approval always rests with them.

Talk to a claims advisor

Providers & schemes we can help you check

Government & public schemes

SHIF — Social Health Insurance Fund Linda Mama EduAfya NHIF (legacy cards)

Eligibility and benefits follow the current rules of the Social Health Authority (SHA) and applicable government programmes.

Private insurers & employer schemes

Jubilee Health AAR APA Britam CIC Madison Resolution Pioneer Minet Old Mutual GA Life Heritage + other licensed insurers

Names shown for identification only — listing does not imply partnership or guarantee of coverage.

Have these ready when we check

  • Insurer or scheme name & policy / member number
  • A clinician's request / prescription for the test
  • Pre-authorisation letter, if your plan requires one

Free coverage check

Ask us to verify your cover

Send your details and our claims team confirms what documents you need and whether pre-authorisation applies — usually the same working day.

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Used only to process your coverage check — see our Privacy Policy. Verification support is free and does not guarantee your provider will pay.

01

Start with fit

Is this the right test for you?

The best test starts with a clear clinical question. These are common reasons a clinician or family may consider this test.

  • ✓Family history of orofacial clefts
  • ✓Previous child born with an orofacial cleft
  • ✓Personal history of orofacial cleft
  • ✓Genetic counseling for individuals concerned about cleft risk
  • ✓Prenatal screening in high-risk pregnancies
02

In plain language

What this test helps you understand

Identifies specific mutations in the IRF6 gene associated with orofacial clefts. Provides information for genetic counseling, risk assessment, and family planning.
The IRF6 Gene Orofacial Cleft Type 6 NGS Genetic DNA Test is a specialized genetic analysis designed to detect mutations within the IRF6 gene. Variations in this gene are linked to the development of orofacial clefts, which affect the lip and/or palate. This test utilizes Next Generation Sequencing (NGS) technology for accurate detection of these genetic changes. Understanding the genetic basis of orofacial clefts can be important for families affected by this condition, potentially aiding in risk assessment and management strategies. This test provides valuable information for individuals and families seeking to understand their genetic predisposition to this condition.
03

Medical review status

Clinical review pending

A completed medical review is not recorded for this page. No clinician has endorsed the information shown here. Please discuss testing decisions with a qualified healthcare professional.

Meet the DNA Labs Kenya medical team →
04

A simple process

What happens next?

You do not have to navigate the test alone. We help you move from question to next step.

1

Speak with us

We check the test and answer your questions before collection.

2

Give your sample

Choose home collection or a coordinated hub visit in Kenya. We explain whether this test uses a cheek swab or blood draw.

3

Understand your report

A counselor helps you understand the result and the next steps.

05

Choose your collection

Home collection or a lab visit

We will explain the sample, preparation, and next steps before anything is collected.

Home collection

Choose a coordinated visit at home or another convenient location. Our team confirms the appointment and sample requirements in advance.

Lab or hub visit

Prefer to visit a coordinated location? We can guide you to the right hub and explain what to expect when you arrive.

Ask about locations →
PreparationNo specific patient preparation is required. Please provide a detailed clinical history and family history prior to the test. A genetic counseling session is recommended before testing.
SampleBlood sample (EDTA tube), extracted DNA, or one drop of blood on an FTA card.
MethodologyNext Generation Sequencing (NGS) is used to detect mutations in the IRF6 gene.
PrivacyYour sample and report are handled confidentially. Ask the team how your information is stored and shared.
This test specifically analyzes the IRF6 gene. Orofacial clefts can be caused by other genetic factors or environmental influences not detected by this test. A negative result does not completely rule out a genetic predisposition. Confirm with the laboratory before booking.
06

Read your report

What common result terms mean

PositiveA finding was identified. Your clinician or counselor will explain what it means for your care.
NegativeThe specific finding tested for was not identified. It does not rule out every possible cause.
VUSA variant was found, but current evidence is not enough to classify it. Your counselor can explain follow-up.
07

Questions people ask

Frequently asked questions

An orofacial cleft is a birth defect that occurs when the lip and/or palate do not fuse completely during pregnancy, resulting in a gap or split.
The IRF6 gene provides instructions for making a protein involved in the development of the face and palate. Mutations in this gene are associated with an increased risk of orofacial clefts.
Individuals with a family history of orofacial clefts, those who have had a child with a cleft, or anyone concerned about the genetic risk should discuss this test with their doctor or a genetic counselor.
This test identifies specific mutations in the IRF6 gene that may contribute to the risk of developing orofacial clefts. It helps understand the genetic basis of the condition in affected families.
Results will be provided through a detailed report. A genetic counselor will be available to explain the findings, their implications, and discuss potential next steps.
Yes, genetic counseling before and after testing is highly recommended to understand the test's implications, interpret results accurately, and discuss family planning options.
08

Collaboration

Open for partnership with hospitals, clinics, doctors & researchers

Whether you are referring patients, building a research programme or supporting students, we work as an extension of your team — with responsive communication and clear scientific standards.

Hospitals & clinics

Referral pathways, coordinated sample logistics and shared reporting that fits your clinical workflow.

Doctors & specialists

LOINC-coded reports, ACMG-based variant classification and a direct scientific line for complex cases.

Research institutions

Sanger sequencing, NGS panels and custom assays — with project design support, batch pricing and agreed turnaround commitments.

Students & academic projects

Discounted laboratory services for college, master's and PhD research projects — including proposal guidance and cost-effective batch testing.

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09

Trust & transparency

Sources, standards & how this page is maintained

Standards & references

  • ACMG/AMP technical standards for sequence variant interpretation
  • ClinGen curation and gene–disease validity frameworks where applicable
  • LOINC-coded reporting for interoperable results
  • ISO 9001:2015 quality management; ISO 15189 accreditation in progress

Page provenance

  • Last updated: September 27, 2026
  • Medical review: not yet completed
  • Written for patients & clinicians in Kenya; reviewed periodically against current guidance

Medical disclaimer: this page is general information, not a diagnosis or personal medical advice. Testing decisions and result interpretation should be made with a qualified healthcare professional.

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