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Medical information Clinical review pending

Genetic Testing

Myeloproliferative Leukemia Mutation Screening MPL S505N W515L

This genetic test detects specific mutations (S505N, W515L) in the MPL gene, which are linked to myeloproliferative neoplasms and leukemia. It aids in diagnosis and treatment planning.

General information only: This page is not a diagnosis or personal medical advice. A qualified clinician should decide whether testing is appropriate and interpret results in context.

Review status: No completed medical review is recorded for this page.

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Counselor guidance included Confidential handling Kenya-wide coordination

At a glance

Plan your test

Sample
Bone marrow aspirate or peripheral blood collected in an EDTA Vacutainer tube (2ml). Confirm specific requirements with the laboratory before booking.
Results
Results are typically available within 5-7 days. Confirm exact turnaround time with the laboratory before booking.
Preparation
No special preparation is required for this test. However, please follow any specific instructions provided by your doctor or the laboratory.
Test priceKSh 13,500

Payment: M-Pesa and card options can be confirmed during booking.

Insurance & government schemes

Is this test covered for you?

We help you verify whether the Myeloproliferative Leukemia Mutation Screening MPL S505N W515L test can be claimed against your insurer, employer scheme or a Kenyan government health scheme — before you book. Coverage depends on your plan, clinical indication and your provider's rules; final approval always rests with them.

Talk to a claims advisor

Providers & schemes we can help you check

Government & public schemes

SHIF — Social Health Insurance Fund Linda Mama EduAfya NHIF (legacy cards)

Eligibility and benefits follow the current rules of the Social Health Authority (SHA) and applicable government programmes.

Private insurers & employer schemes

Jubilee Health AAR APA Britam CIC Madison Resolution Pioneer Minet Old Mutual GA Life Heritage + other licensed insurers

Names shown for identification only — listing does not imply partnership or guarantee of coverage.

Have these ready when we check

  • Insurer or scheme name & policy / member number
  • A clinician's request / prescription for the test
  • Pre-authorisation letter, if your plan requires one

Free coverage check

Ask us to verify your cover

Send your details and our claims team confirms what documents you need and whether pre-authorisation applies — usually the same working day.

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Used only to process your coverage check — see our Privacy Policy. Verification support is free and does not guarantee your provider will pay.

01

Start with fit

Is this the right test for you?

The best test starts with a clear clinical question. These are common reasons a clinician or family may consider this test.

  • ✓Suspected myeloproliferative neoplasm (MPN)
  • ✓Diagnosis of leukemia
  • ✓Monitoring disease progression
  • ✓Guiding treatment decisions
  • ✓Evaluating risk factors for blood disorders
  • ✓Family history of MPNs or leukemia
02

In plain language

What this test helps you understand

This test helps identify specific genetic mutations associated with myeloproliferative neoplasms, aiding in diagnosis, prognosis, and treatment planning for conditions like leukemia.
This test screens for mutations in the MPL gene, specifically the S505N and W515L variants. These mutations are associated with myeloproliferative neoplasms (MPNs), a group of blood disorders that can potentially develop into leukemia. Identifying these mutations can provide valuable information for diagnosis and guiding treatment decisions. This test is important for understanding the underlying genetic factors contributing to certain blood conditions. Results are interpreted by a healthcare professional to determine the best course of action.
03

Medical review status

Clinical review pending

A completed medical review is not recorded for this page. No clinician has endorsed the information shown here. Please discuss testing decisions with a qualified healthcare professional.

Meet the DNA Labs Kenya medical team →
04

A simple process

What happens next?

You do not have to navigate the test alone. We help you move from question to next step.

1

Speak with us

We check the test and answer your questions before collection.

2

Give your sample

Choose home collection or a coordinated hub visit in Kenya. We explain whether this test uses a cheek swab or blood draw.

3

Understand your report

A counselor helps you understand the result and the next steps.

05

Choose your collection

Home collection or a lab visit

We will explain the sample, preparation, and next steps before anything is collected.

Home collection

Choose a coordinated visit at home or another convenient location. Our team confirms the appointment and sample requirements in advance.

Lab or hub visit

Prefer to visit a coordinated location? We can guide you to the right hub and explain what to expect when you arrive.

Ask about locations →
PreparationNo special preparation is required for this test. However, please follow any specific instructions provided by your doctor or the laboratory.
SampleBone marrow aspirate or peripheral blood collected in an EDTA Vacutainer tube (2ml). Confirm specific requirements with the laboratory before booking.
MethodologyMolecular genetic testing, specifically DNA sequencing or mutation-specific assays, is used to detect the presence of the MPL S505N and W515L mutations.
PrivacyYour sample and report are handled confidentially. Ask the team how your information is stored and shared.
This test only detects the specific MPL S505N and W515L mutations. It does not screen for other genetic mutations associated with leukemia or MPNs. A negative result does not rule out the presence of other mutations or a diagnosis of leukemia. Confirm with the laboratory before booking.
06

Read your report

What common result terms mean

PositiveA finding was identified. Your clinician or counselor will explain what it means for your care.
NegativeThe specific finding tested for was not identified. It does not rule out every possible cause.
VUSA variant was found, but current evidence is not enough to classify it. Your counselor can explain follow-up.
07

Questions people ask

Frequently asked questions

The MPL gene provides instructions for making a protein that is involved in the production of platelets, a type of blood cell. Mutations in this gene can affect platelet production and contribute to blood disorders.
MPNs are a group of blood cancers where the bone marrow produces too many of certain types of blood cells, such as red blood cells, white blood cells, or platelets. This test helps identify genetic factors associated with some MPNs.
Yes, a doctor's prescription is generally required for this test, except in specific circumstances like planned surgery, pregnancy, or travel abroad. Please consult your doctor.
A positive result indicates the presence of one or both of the specified MPL mutations. Your doctor will interpret this result in the context of your overall health and other test results to guide diagnosis and treatment.
Home sample collection services may be available. Please contact the laboratory directly at +254711564616 to inquire about availability and scheduling.
08

Collaboration

Open for partnership with hospitals, clinics, doctors & researchers

Whether you are referring patients, building a research programme or supporting students, we work as an extension of your team — with responsive communication and clear scientific standards.

Hospitals & clinics

Referral pathways, coordinated sample logistics and shared reporting that fits your clinical workflow.

Doctors & specialists

LOINC-coded reports, ACMG-based variant classification and a direct scientific line for complex cases.

Research institutions

Sanger sequencing, NGS panels and custom assays — with project design support, batch pricing and agreed turnaround commitments.

Students & academic projects

Discounted laboratory services for college, master's and PhD research projects — including proposal guidance and cost-effective batch testing.

Explore partnerships
09

Trust & transparency

Sources, standards & how this page is maintained

Standards & references

  • ACMG/AMP technical standards for sequence variant interpretation
  • ClinGen curation and gene–disease validity frameworks where applicable
  • LOINC-coded reporting for interoperable results
  • ISO 9001:2015 quality management; ISO 15189 accreditation in progress

Page provenance

  • Last updated: September 27, 2026
  • Medical review: not yet completed
  • Written for patients & clinicians in Kenya; reviewed periodically against current guidance

Medical disclaimer: this page is general information, not a diagnosis or personal medical advice. Testing decisions and result interpretation should be made with a qualified healthcare professional.

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