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Genetic Testing

NDUFAF3 Gene Mitochondrial Complex I Deficiency Genetic Test

Genetic test for NDUFAF3 gene mutations linked to mitochondrial complex I deficiency, often causing neurological symptoms. Uses Next Generation Sequencing (NGS) technology.

General information only: This page is not a diagnosis or personal medical advice. A qualified clinician should decide whether testing is appropriate and interpret results in context.

Review status: No completed medical review is recorded for this page.

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Counselor guidance included Confidential handling Kenya-wide coordination

At a glance

Plan your test

Sample: Blood sample (usually collected in an EDTA tube). Confirm specific requirements with the laboratory before booking.
Results: Confirm with the laboratory before booking.
Preparation: Generally, no special preparation is required for a blood draw. However, confirm with the laboratory for any specific instructions.

Test priceKSh 40,000

Payment: M-Pesa and card options can be confirmed during booking.

Insurance & government schemes

Is this test covered for you?

We help you verify whether the NDUFAF3 Gene Mitochondrial Complex I Deficiency Genetic Test test can be claimed against your insurer, employer scheme or a Kenyan government health scheme — before you book. Coverage depends on your plan, clinical indication and your provider's rules; final approval always rests with them.

Talk to a claims advisor

Providers & schemes we can help you check

Government & public schemes

SHIF — Social Health Insurance Fund Linda Mama EduAfya NHIF (legacy cards)

Eligibility and benefits follow the current rules of the Social Health Authority (SHA) and applicable government programmes.

Private insurers & employer schemes

Jubilee Health AAR APA Britam CIC Madison Resolution Pioneer Minet Old Mutual GA Life Heritage + other licensed insurers

Names shown for identification only — listing does not imply partnership or guarantee of coverage.

Have these ready when we check

Insurer or scheme name & policy / member number
A clinician's request / prescription for the test
Pre-authorisation letter, if your plan requires one

Free coverage check

Ask us to verify your cover

Send your details and our claims team confirms what documents you need and whether pre-authorisation applies — usually the same working day.

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Used only to process your coverage check — see our Privacy Policy. Verification support is free and does not guarantee your provider will pay.

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Start with fit

Is this the right test for you?

The best test starts with a clear clinical question. These are common reasons a clinician or family may consider this test.

✓Unexplained neurological symptoms (e.g., muscle weakness, seizures, developmental delays)
✓Suspected mitochondrial disorder
✓Family history of mitochondrial disease
✓Referral from a neurologist or geneticist
✓Evaluation of Leigh syndrome or related disorders

In plain language

What this test helps you understand

This test helps identify mutations in the NDUFAF3 gene associated with mitochondrial complex I deficiency. It can aid in the diagnosis of individuals presenting with symptoms suggestive of this condition, particularly neurological disorders. Genetic results may inform prognosis, management strategies, and family planning.

The NDUFAF3 Gene Mitochondrial Complex I Deficiency NGS Genetic DNA Test is a diagnostic tool used to identify specific genetic changes in the NDUFAF3 gene. This gene provides instructions for making a protein that is part of mitochondrial complex I, which is essential for energy production within cells. Mutations in this gene can lead to mitochondrial complex I deficiency, a condition that can cause a range of symptoms, particularly affecting the nervous system. This test utilizes advanced Next Generation Sequencing (NGS) technology to detect variations in the NDUFAF3 gene. Understanding these genetic variations can help in diagnosing mitochondrial disorders and guiding appropriate medical management.

Medical review status

Clinical review pending

A completed medical review is not recorded for this page. No clinician has endorsed the information shown here. Please discuss testing decisions with a qualified healthcare professional.

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A simple process

What happens next?

You do not have to navigate the test alone. We help you move from question to next step.

Speak with us

We check the test and answer your questions before collection.

Give your sample

Choose home collection or a coordinated hub visit in Kenya. We explain whether this test uses a cheek swab or blood draw.

Understand your report

A counselor helps you understand the result and the next steps.

Choose your collection

Home collection or a lab visit

We will explain the sample, preparation, and next steps before anything is collected.

Home collection

Choose a coordinated visit at home or another convenient location. Our team confirms the appointment and sample requirements in advance.

Lab or hub visit

Prefer to visit a coordinated location? We can guide you to the right hub and explain what to expect when you arrive.

Ask about locations →

PreparationGenerally, no special preparation is required for a blood draw. However, confirm with the laboratory for any specific instructions.

SampleBlood sample (usually collected in an EDTA tube). Confirm specific requirements with the laboratory before booking.

MethodologyNext Generation Sequencing (NGS) of the NDUFAF3 gene.

PrivacyYour sample and report are handled confidentially. Ask the team how your information is stored and shared.

This test analyzes the NDUFAF3 gene specifically. It may not detect mutations in other genes that can cause similar symptoms. The test may not identify all possible types of mutations (e.g., large deletions or rearrangements). Results should be interpreted alongside clinical findings.

Read your report

What common result terms mean

TermPlain-language meaning

PositiveA finding was identified. Your clinician or counselor will explain what it means for your care.

NegativeThe specific finding tested for was not identified. It does not rule out every possible cause.

VUSA variant was found, but current evidence is not enough to classify it. Your counselor can explain follow-up.

Questions people ask

Frequently asked questions

Mitochondrial complex I deficiency is a condition where the first complex in the electron transport chain, crucial for energy production in cells, does not function properly. This can affect organs with high energy demands, like the brain and muscles.

The NDUFAF3 gene provides instructions for making a protein that is a component of mitochondrial complex I. Proper function of this protein is essential for the complex to work correctly.

Individuals with symptoms like unexplained muscle weakness, seizures, developmental delays, or a family history of mitochondrial disorders may be candidates for this test, often following referral from a specialist.

Results are interpreted by geneticists or other qualified healthcare professionals. They consider the specific genetic findings in relation to your symptoms, medical history, and family history.

Discuss your results with your doctor or a genetic counselor. They can explain the implications, discuss potential management options, and advise on genetic counseling for you and your family.

Collaboration

Open for partnership with hospitals, clinics, doctors & researchers

Whether you are referring patients, building a research programme or supporting students, we work as an extension of your team — with responsive communication and clear scientific standards.

Hospitals & clinics

Referral pathways, coordinated sample logistics and shared reporting that fits your clinical workflow.

Doctors & specialists

LOINC-coded reports, ACMG-based variant classification and a direct scientific line for complex cases.

Research institutions

Sanger sequencing, NGS panels and custom assays — with project design support, batch pricing and agreed turnaround commitments.

Students & academic projects

Discounted laboratory services for college, master's and PhD research projects — including proposal guidance and cost-effective batch testing.

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Trust & transparency

Sources, standards & how this page is maintained

Standards & references

ACMG/AMP technical standards for sequence variant interpretation
ClinGen curation and gene–disease validity frameworks where applicable
LOINC-coded reporting for interoperable results
ISO 9001:2015 quality management; ISO 15189 accreditation in progress

Page provenance

Last updated: September 27, 2026
Medical review: not yet completed
Written for patients & clinicians in Kenya; reviewed periodically against current guidance

Medical disclaimer: this page is general information, not a diagnosis or personal medical advice. Testing decisions and result interpretation should be made with a qualified healthcare professional.

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